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. 2020 Feb 14;11:899. doi: 10.1038/s41467-020-14754-7

Fig. 1. Depolymerization of HM-type N-glycans by B. thetaiotaomicron.

Fig. 1

BT3987 deglycosylates HM-glycoproteins in the cell surface. The HM product interacts with the surface glycan binding protein (SGBP), BT3986, and the SusD homolog BT3984 interacts with the reducing end GlcNAc, orientating the glycan into the SusC homolog BT3983 porin. The HM glycan is transported to the periplasm where it is processed by three mannosidases to the trisaccharide Man-α-1,6-Man-β1,4-GlcNAc. Cartoon representation of BT3987 (PDB CODE 6T8I) and BT3990 (PDB CODE 2WVZ), and surface representation of BT3984 (PDB CODE 3CGH; 7).