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. 2020 Jan 16;14(1):1–11. doi: 10.1007/s12105-019-01112-3

Table 1.

Key genetic alterations in liposarcoma subtypes

Tumor type Cytogenetic alterations Associated genes
Atypical lipomatous tumor/well-differentiated liposarcoma Ring or giant marker chromosomes (12q13-15) Amplification of MDM2, CDK4, HMGA2, YEATS4, FRS2, PTPRQ, DDIT3 and others
Dedifferentiated liposarcoma Ring or giant marker chromosomes (12q13-15) Amplification of MDM2, CDK4, HMGA2, YEATS4, FRS2, PTPRQ, DDIT3 and others
Myxoid liposarcoma

t(12;16)(q13;p11)

t(12;22)(q13;q12)

FUS-DDIT3

EWSR1-DDIT3
Pleomorphic liposarcoma Complex karyotypic alterations Modification of TP53, NF1, and RB1