ALES is a highly infiltrative tumor (a, 2x) consisting of sheets, lobules, and nests of basaloid tumor cells embedded in fibrous (b, 4x), myxoid (c, 4x), and hyalinized (d, 4x) stroma. Thyroid ALES tend to colonize existing follicular structures (e, 4x) while sinonasal tumors occasionally colonize surface epithelium (d, 10x)