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Desmoplastic squamous cell carcinoma: This large tumor is characterized by an abundant eosinophilic desmoplastic stroma (a). Pleomorphic tumor cells are arranged singly or in small groups in the densely sclerotic stroma (b). By immunohistochemistry, tumor cells in this spindle cell squamous cell carcinoma express cytokeratins multifocally (c) and there is strong and diffuse expression of CD10 (d)
