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Dedifferentiated Melanoma: This nodular tumor is based within dermis (a) and shows ulceration of the overlying epidermis (b). There is a background of adjacent melanoma in situ (d). Melan a immunohistochemistry highlights the in-situ melanoma and small focus of conventional invasive melanoma. The spindle cell component is melan a negative (e) and show strong and diffuse expression of CD10
