Fig. 1.

Study Design. ACR20 indicates American College of Rheumatology composite measure defined as a 20% decrease in swollen joint count and tender joint count, as well as a 20% improvement in at least three of the following five measures: subject assessment of pain, subject global assessment of disease activity, physician global assessment of disease activity, C-reactive protein or erythrocyte sedimentation rate, and Health Assessment Questionnaire Disability Index; DB double-blind, R randomized