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. 2020 Jan 24;117(6):3135–3143. doi: 10.1073/pnas.1918673117

Fig. 3.

Fig. 3.

Changes in mature meniscus of AcanCreERT2-FoxO TKO mice. (A) Meniscus scores (0 to 25) and grading (0 to IV) of AcanCreERT2 TKO mice at 5 mo after tamoxifen (TMX) injection. WT: Littermate AcanCreERT2-negative mice that also received tamoxifen injections. (B) Meniscus scores and grading of 6-mo-old AcanCreERT2 TKO mice in specific meniscus regions after 6-wk treadmill running. (C) Meniscus scores and grading of 6-mo-old AcanCreERT2 TKO mice in specific meniscus regions 8 wk after DMM surgery. (n = 6 per groups, *P < 0.05). (D) Safranin-O staining of AcanCreERT2 TKO mice at 5 mo after TMX injection. (E) Safranin-O staining of AcanCreERT2 TKO mice in specific meniscus regions after 6-wk treadmill running. (F) Safranin-O staining of 6-mo-old AcanCreERT2 TKO mice in specific meniscus regions after DMM surgery (PO 8 wk). (Scale bar: 100 μm.)