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. 2020 Jan 24;117(6):3135–3143. doi: 10.1073/pnas.1918673117

Fig. 4.

Fig. 4.

Histopathology of meniscus and articular cartilage in mice with FoxO deletion. Meniscus total scores (0 to 25) and grading (0 to IV) and articular cartilage OARSI total scores (0 to 24) and grades (I through VI) of Col2Cre-FoxO TKO, Col2Cre-FoxO single KO1, KO3, KO4. (A) Meniscus scores and grades of Col2Cre-FoxO TKO mice at 2, 4, 6, 12, and 18 mo old; (B) OARSI scores and grades of Col2Cre-FoxO TKO mice at 2, 4, 6, 12, and 18 mo old; (C) meniscus scores and grades of Col2Cre-FoxO conditional KO mice at 2, 4, 6, 12, and 18 mo old; and (D) OARSI scores and grades of Col2Cre-FoxO conditional KO mice at 2, 4, 6, 12, and 18 mo old (n = 6 per group, *P < 0.05).