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. 2020 Jan 23;117(6):2914–2922. doi: 10.1073/pnas.1917525117

Fig. 2.

Fig. 2.

Hyperkeratosis and impaired formation of lipid lamellae and keratohyalin granules in Fatp4 KO mice. (A) Paraffin sections of E18.5 WT and Fatp4 KO mouse skin were prepared and stained with hematoxylin and eosin, and bright field images were photographed. (Scale bars, 20 μm.) (B–D) Ultrathin sections of E18.5 WT and Fatp4 KO mouse skin were prepared and subjected to transmission electron microscopy. (B) Red arrowheads indicate keratohyalin granules. (Scale bars, 10 μm.) (C) Enlarged views of the yellow boxes in B. Magenta and light blue arrowheads indicate curved membrane structures and vacuoles in corneocytes, respectively. (Scale bars, 5 μm.) (D) Enlarged views of the curved membrane structures observed in Fatp4 KO mouse skin are shown. (Scale bars, 1 μm.) SC, stratum corneum; SG, stratum granulosum; SS, stratum spinosum; SB, stratum basale.