Fig. 4.
Effects of glucagon on glycoNOE contrast in the liver of fed mice. (A) The experimental scheme: UTE-ST MRI experiments (B1 = 0.7 µT) were conducted before and after glucagon (100 µL, 1 mg/mL) injection. (B–D) Z-spectral changes after glucagon for the indicated region of interest. Shaded areas indicate signal changes over the glycoNOE region (−0.6 to −1.5 ppm). (E) glycoNOE maps as a function of time before and after injection. (F) Average (n = 5) glycoNOE and “glycoCEST + H1-4 NOE” signal changes as a function of time in mouse liver. The average glycogen concentration changes (right y axis) were calculated from glycoNOE signal. The T2 image and glycoNOE map have been magnified 1.3×.