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Bcl-2-like proteins in basal metazoan clades and potential apoptosis model. (a) Metazoan phylogenetic relationships and the presence or absence of Bcl-2 proteins. The presence or absence of Bcl-2 family members is indicated. (b) A simple model for intrinsic apoptosis in Porifera and Placozoa where BH3-only proteins have not been identified. Experiments have yet to delineate the roles of MOMP and adaptor protein initiation of caspases in their entirety.
