Figure 3.

Storage stability of (A) particle size, (B) polydispersity index (PDI), (C) zeta potential, and (D) encapsulation efficiency of the lyophilized and liquid suspension nanoparticles during 3 months of storage at 20 °C. Data expressed as mean ± SD (n = 3). Statistical comparisons of the means were performed using the two-way analysis of variance and differences between groups compared using Tukey’s multiple comparisons test. * p < 0.05; ** p < 0.01; **** p < 0.0001 compared with the corresponding T0 (measurement after synthesis). • p < 0.05; •• p < 0.01; ••• p < 0.001; •••• p < 0.0001 compared with the corresponding placebo at the same time-point.