Table 2.

Observed responses in Box–Behnken design for rifapentine (RPT)-loaded nanostructured lipid carriers (NLCs).

Sample	Independent Variables			Dependent Variables
	X1 (mg)	X2 (mg)	X3 (mg)	Y1 (nm)	Y2 (%)	Y 3
1	250	50	80	235	90.3	3.01
2	350	50	80	311	86.8	2.17
3	250	150	80	275	85.8	2.15
4	350	150	80	334	78.7	1.57
5	250	100	60	317	75.5	2.16
6	350	100	60	330	86.6	1.92
7	250	100	100	207	75.0	2.14
8	350	100	100	294	67.2	1.49
9	300	50	60	271	87.4	2.50
10	300	150	60	322	69.2	1.54
11	300	50	100	251	75.2	2.15
12	300	150	100	272	84.8	1.89
13	300	100	80	277	84.9	2.12
14	300	100	80	254	89.1	2.23
15	300	100	80	282	83.2	2.08

The independent variables were the amounts of solid lipid (X₁), liquid lipid (X₂), and surfactant (X₃), while mean hydrodynamic particle size (Y₁), encapsulation efficiency (Y₂), and loading capacity (Y₃) were the dependent variables in study.