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. 2020 Feb 14;94(5):e01774-19. doi: 10.1128/JVI.01774-19

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Copyright © 2020 American Society for Microbiology.

This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 5 — Antibodies against MERS-CoV fail to neutralize MERS-Uganda chimera. (A) Structure of the MERS-CoV spike trimer with therapeutic antibody LCA60 bound adjacent to the receptor-binding domain and the antibody G4 bound to the S2 portion. Consensus amino acids are outlined for the S1 (gray) and S2 (black) domains, with PDF-2180 differences noted in magenta. (B and C) Plaque neutralization curves for LCA60 (B) and G4 (C) with (solid) and without (dotted) trypsin treatment for MERS-CoV (black) and MERS-Uganda chimera (magenta) (n = 3 per concentration).