FIG 7.

Complete blood count graphs of animals rechallenged with ZIKV-PR. (A) Schematic of animals included in this study. (B) Clinical hematology was performed by WNPRC on whole blood collected daily from macaques on days 3 to 7, as well as on days −3, 0, 10, 14, and 28 after ZIKV rechallenge. Horizontal dotted lines indicate the range of normal reference intervals (RI). Four of five animals had lymphocyte levels dip below the RI (20 to 80% of WBC) at 3 days after exposure but rebounded to the levels within the normal range by 4 days after exposure. Mild monocytosis exceeding the RI (0 to 3% of the WBC) was reported in animal C2 7 days prior to rechallenge. Animal C5 had platelet values exceeding the RI (229,000 to 524,000 platelets ths/μl) ranging from 575,000 to 747,000 platelets ths/μl present at day −3 and continuing until day 28. Thrombocytosis was also noted following the initial ZIKV challenge for this animal. No other abnormal CBC data were reported.