TABLE 1.
Animal demographicsa
Animal | PAI | Initial |
Rechallenge |
Other infection, dpi | |||
---|---|---|---|---|---|---|---|
Statusb | ZIKV inoculation strain | Inoculation dose in PFU (s.c.) | ZIKV inoculation strain, dpi | Inoculation dose in PFU (s.c.) | |||
C1 | 295022 | NP | ZIKV-MR766 | 104 | ZIKV-FP, 70 | 104 | SHIV, 347 |
ZIKV-PR, 858 | 104 | ||||||
C2 | 321142 | NP | ZIKV-FP | 106 | ZIKV-PR, 675 | 104 | DENV3, 164 |
C3 | 598248 | P | ZIKV-FP | 104 | ZIKV-PR, 809 | 104 | None |
C4 | 610107 | NP | ZIKV-FP | 106 | ZIKV-FP, 70 | 104 | SHIV, 326 |
ZIKV-PR, 837 | 104 | ||||||
C5 | 827577 | P | ZIKV-FP | 104 | ZIKV-PR, 858 | 104 | None |
Public animal identifiers (PAI) are used in studies on the Zika Open Research Portal (https://zika.labkey.com/project/OConnor/begin.view?). All animals were female. Animal C1 was previously infected with 104 PFU of ZIKV-MR766 and rechallenged with 104 PFU of ZIKV-FP 70 days after initial ZIKV infection (45). Animal C2 was previously infected with 106 PFU ZIKV-FP and Dengue virus 3 164 days prior to initial ZIKV infection (47). Animals C5 and C3 were previously infected with 104 PFU of ZIKV-FP during their first and late second/early third trimesters of pregnancy, respectively (46). Animal C4 was previously infected with 106 PFU of ZIKV-FP and rechallenged 70 days after initial infection with104 PFU of ZIKV-FP (44). All animals were rechallenged with 104 PFU of ZIKV-PR 675 to 858 days after initial infection. ZIKV-MR766, Zika virus/R.macaque- tc/UGA/1947/MR766-3329; ZIKV-FP, Zika virus/H.sapiens-tc/FRA/2013/FrenchPolynesia-01_v1c1; ZIKV-PR, Zika virus/H.sapiens-tc/PUR/2015/PRVABC59. dpi, days after initial ZIKV infection.
The pregnancy status at the time of initial infection: NP, nonpregnant; P, pregnant.