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Model of vIL-6 induction of ITGB3. Expression of vIL-6 augments JAK/STAT3 activation increasing the levels of ITGB3, which results in higher surface expression of the heterodimer αVβ3 integrin. This process promotes vIL-6-induced endothelial cell adhesion to the ECM components fibronectin and vitronectin and promotes tubule formation. The illustration was designed using BioRender.
