TABLE 1.
Study | Animal | Challenge virus | No. of challenges |
Age at first exposure (wks) |
Age at infection (wks) |
Infection duration |
Age at necropsy (wks) |
Peak viremia (no. of copies/ml) |
Necropsy viremia (no. of copies/ml) |
---|---|---|---|---|---|---|---|---|---|
1a | 1A | SIVmac251 | 2 | 12 | 14 | 13 | 25 | 89,000,000 | 16,000,000 |
1B | SIVmac251 | 10 | 12 | 22 | 12 | 24 | 48,000,000 | 900,000 | |
1C | SIVmac251 | 2 | 12 | 14 | 13 | 25 | 230,000,000 | 200,000,000 | |
1D | SIVmac251 | 1 | 12 | 13 | 13 | 25 | 16,000,000 | 1,700,000 | |
1E | SIVmac251 | 1 | 12 | 13 | 12 | 24 | 16,000,000 | 7,400,000 | |
2b | 2A | SHIV1157ipd3N4 | 18 | 12 | 30 | 6 | 18 | 210,000 | 4,600 |
2B | SHIV1157ipd3N4 | 3 | 12 | 15 | 7 | 19 | 590,000 | 1,500 | |
2C | SHIV1157ipd3N4 | 3 | 12 | 14 | 8 | 20 | 26,000,000 | 910,000 | |
2D | SHIV1157ipd3N4 | 16 | 12 | 28 | 6 | 18 | 64,000,000 | 220,000 | |
2E | SHIV1157ipd3N4 | 1 | 12 | 12 | 7 | 19 | 33,000,000 | 58,000 | |
2F | SHIV1157ipd3N4 | 13 | 12 | 25 | 6 | 18 | 16,000 | 250 | |
3 | 3A | SHIV.C.CH505.375H.dCT | 2 | 6 | 8 | 27 | 36 | 4,700,000 | 18,000 |
3B | SHIV.C.CH505.375H.dCT | 2 | 6 | 8 | 27 | 35 | 2,800,000 | 1,300 | |
3C | SHIV.C.CH505.375H.dCT | 17 | 6 | 23 | 23 | 42 | 1,000,000 | 1,000,000 | |
3D | SHIV.C.CH505.375H.dCT | 2 | 6 | 8 | 25 | 35 | 2,900,000 | 20 |