FIG 1.

Structures of the linear and circular forms of the ZIKV genome. Based on the predictions and structural models identified by Li et al. in a recent study (59), the conserved RNA structures in the 5ʹ and 3ʹ ends of the genome are indicated, and the UAR, DAR, and CS sequences are highlighted in orange, green, and red, respectively, in the linear genome. The pairwise hybridizations between the 5ʹ UAR and the 3ʹ UAR, the 5ʹ DAR and the 3ʹ DAR, and the 5ʹ CS and the 3ʹ CS are shown in the circular form of the genome. The cis-acting element sequence present in the capsid-coding region (cHP) is present only in the linear form. The structures of the SLB, the sHP, and the bottom of the 3ʹ SL are changed in the circular form of the genome. The bent arrows denote the translation start site.