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. 2020 Jan 16;10(1):149. doi: 10.3390/biom10010149

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of intracerebroventricular (i.c.v.) injection of methamphetamine (MA) on pulsatile arterial pressure (PAP) and mean arterial pressure (MAP) in urethane-anesthetized Sprague Dawley (SD) rats. (A) Representative recordings of i.c.v. MA (50, 150, and 500 nmol) induced an increase in PAP and MAP in three SD rats. (B) Bar graph shows the increase in MAP by i.c.v. injection of saline and MA. MA was injected 30 min after saline injection. Values represent the mean + SEM, n = 6 animals in each group. * p = 0.0306, ** p = 0.0005, and *** p < 0.0001 versus corresponding saline analyzed by paired t-test. # p < 0.05 and ## p < 0.001 versus MA 50 analyzed by one-way ANOVA followed by Bonferroni’s multiple comparison post-test.