Table 1.
Blood concentration level of TRP and its metabolites, alongside some significant ratios, compared with the coronary heart disease (CHD) and the control groups.
| Metabolites | Range | Total (n = 103) | CHD Group (n = 31) | Control Group (n = 72) | p-Value |
|---|---|---|---|---|---|
| TRP (mM) | 0.04–0.17 | 0.06 ± 0.03 | 0.06 ± 0.02 | 0.07 ± 0.03 | 0.076 |
| KYN (mM) | 0.70–306.87 | 71.68 ± 60.88 | 41.98 ± 47.68 | 84.47 ± 61.74 | <0.001 |
| KA (mM) | 0–0.07 | 0.005 ± 0.01 | 0.003 ± 0.004 | 0.007 ± 0.01 | 0.078 |
| XAN (mM) | 0–0.28 | 0.03 ± 0.04 | 0.03 ± 0.04 | 0.02 ± 0.04 | 0.131 |
| HAA (mM) | 0–0.88 | 0.02 ± 0.09 | 0.01 ± 0.03 | 0.02 ± 0.10 | 0.062 |
| QA (mM) | 0.04–4.07 | 0.61 ± 0.85 | 0.30 ± 0.23 | 0.74 ± 0.98 | 0.124 |
| PA (mM) | 0–7.81 | 0.74 ± 1.11 | 0.83 ± 1.04 | 0.70 ± 1.15 | 0.165 |
| HIAA (mM) | 0–364.59 | 22.75 ± 44.12 | 27.45 ± 70.41 | 20.73 ± 26.22 | 0.018 |
| KYN/XAN (×104) | 0–17.83 | 1.48 ± 2.66 | 0.73 ± 1.51 | 1.78 ± 2.97 | 0.001 |
| KYN/TRP (×103) | 0–7.00 | 1.15 ± 1.08 | 0.72 ± 0.70 | 1.34 ± 1.16 | 0.002 |
| XAN/KA | 0–229.84 | 18.83 ± 36.76 | 32.22 ± 53.56 | 13.06 ± 24.85 | 0.015 |
| HAA/XAN | 0–32.33 | 1.94 ± 3.94 | 1.17 ± 1.92 | 2.27 ± 4.52 | 0.029 |
| QA/XAN (×103) | 0–1.30 | 0.11 ± 0.23 | 0.05 ± 0.07 | 0.14 ± 0.26 | 0.018 |
| PA/HAA (×103) | 0–3.33 | 0.25 ± 0.52 | 0.33 ± 0.68 | 0.22 ± 0.44 | 0.043 |
| PA/HIAA | 0–4.37 | 0.13 ± 0.46 | 0.29 ± 0.81 | 0.06 ± 0.14 | 0.028 |
| PA/KYN | 0–0.45 | 0.03 ± 0.06 | 0.05 ± 0.09 | 0.02 ± 0.04 | 0.001 |
| PA/KA (×104) | 0–1.11 | 0.07 ± 0.13 | 0.06 ± 0.07 | 0.07 ± 0.15 | 0.044 |
| Age (years) | 21–86 | 54.48 ± 13.88 | 58.16 ± 13.34 | 52.89 ± 13.90 | 0.056 |
The values are presented as means ± SD. A nonparametric Mann–Whitney U-test used for comparing between groups at p < 0.05. Abbreviations: QA = quinolinic acid; PA = picolinic acid; HAA = 3-hydroxyanthranillic acid; HIAA = 5-hydroxyindoleacetic acid; KYN = kynurenine; XAN = xanthurenic acid; TRP = tryptophan; KA = kynurenic acid.