Table 3.
Studies (2009–2019) that investigate the virulence and pathogenicity of Aeromonas spp. using different cell lines (adapted from [20]).
| Cell Line | Study | Aeromonas | Reference |
|---|---|---|---|
| HEp-2, Vero | Adhesion and cytotoxicity |
A. hydrophila. A. salmonicida, A. veronii, A. bestiarum, A. schuberti, A. eucrenophila, A. encheleia, A. jandaei, A. sobria, A. caviae, A. trota, A. media |
[311] |
| HEp-2, CHO | Cell-contact cytotoxicity | A. hydrophila, A. caviae, A. veronii | [310] a |
| C2C12 | Cytotoxicity | A. hydrophila, A. dhakensis | [68] |
| HEp-2 | Adhesion, biofilm formation, and immune stimulation | A. hydrophila | [289] |
|
HEp-2, Caco-2,
T-84 |
Adhesion, invasion, and cytotoxicity | A. hydrophila, A. caviae | [308] a |
| RAW 264.7 | Role of mixed infections in Necrotizing fasciitis | A. hydrophila | [187] |
| Caco-2 | Adhesion and cytopathic effect |
A. hydrophila, A. dhakensis, A. bestiarum, A. piscicola, A. salmonicida |
[312] |
| HepG2, WLR-68 | Cytotoxicity effect of metalloprotease | A. hydrophila | [313] a |
| Caco-2 | Adhesion, invasion, and cytotoxicity | A. salmonicida | [314] |
| J744.1 | Role of metallochaperone HypA | A. hydrophila | [273] |
| RAW 264.7 | Role of mixed infections in Necrotizing fasciitis | A. hydrophila | [188] |
Human epithelial cell line (HEp-2), kidney epithelial cells from African green monkey (Vero), Chinese hamster ovary cell line (CHO), mouse myoblast cell line (C2C12), human epithelial colorectal adenocarcinoma cell line (Caco-2), human colorectal adenocarcinoma cell line (T-84), murine macrophages cell line (RAW 264.7), hepatic cell line (WLR-68). a The strains were identified by non-molecular methods (RFLP, phenotypic characteristics, virulence factors).