Table 1.

Clinical trials for the evaluation of the activity of antimalarials on viral infections in patients.

Virus Family	Virus Species	Drug	Trial Number/Reference	Outcome
Herpesviridae	HCMV	Artesunate	NCT00284687	No results
Papillomaviridae	HPV	Artesunate	NCT03100045	Ongoing
			NCT04098744	Ongoing
Flaviviridae	HCV	Hydroxychloroquine	NCT01833845	Terminated due to failure to recruit subjects
			NCT01272310	Unknown
	DENV	Chloroquine	NCT00849602	Reduction in pain but not in length of disease [36]
	CHIKV	Chloroquine	NCT003913131	No difference between CQ- and placebo-treated groups [37]
Orthomyxoviridae	IAV	Chloroquine	NCT01078779	No prevention of IAV infection [38]
Retroviridae	HIV	Hydroxychloroquine	[39,40]	Reduction in HIV-1 RNA load in plasma
		Hydroxychloroquine	ISRCTN30019040	Increased HIV-1 replication and decreased CD4 numbers [41]
		Chloroquine	NCT00819390	Modest reduction in immune activation [42]
		Chloroquine	NCT02004314	Patients did not experience any improvement after CQ treatment [43]
		Chloroquine	NCT01650558	Terminated, awaiting results [44,45]