Table 3.
Top ten Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway analyses of the four chosen EV-miRNAs. Pathways are listed according to the target-genes (#genes) of the four miRNAs (#miRNAs) analyzed.
| KEGG Pathway | p-value | #genes | #miRNAs |
|---|---|---|---|
| Pathways in cancer | 9.95 × 10−5 | 62 | 3 |
| Viral carcinogenesis | 3.10 × 10−5 | 42 | 3 |
| Human T-cell lymphotropic virus type 1 (HTLV-I) infection | 0.044937 | 40 | 3 |
| MicroRNAs in cancer | 0.038582 | 37 | 3 |
| Mitogen-activated protein kinase (MAPK) signaling pathway | 0.03917 | 37 | 3 |
| Transcriptional misregulation in cancer | 0.001051 | 33 | 3 |
| Protein processing in endoplasmic reticulum | 0.028384 | 31 | 3 |
| Thyroid hormone signaling pathway | 0.001618 | 29 | 3 |
| Proteoglycans in cancer | 0.004657 | 29 | 3 |
| RNA transport | 0.029074 | 28 | 3 |