Figure 2.

Flowchart of the in silico experiment for inferring oncogenes. (A) Reconstruct the cancer and normal models. (B) Compute the flux distributions of cancer and normal models. (C) Build the flux template according to the flux distributions of cancer and normal models. (D)–(I) Simulation of a wet lab experiment for determining oncogenes. Orange arrows indicate the building processes of the flux template that acted as the control in the oncogene inference problem. Red arrows present the mutant schemes for formulating the tri-level oncogene inference problem.