Table 2.
Top six one-hit reactions. The criteria may overestimate or underestimate compared with the results solved by the pseudo-enzyme strategy.
| Reaction | Gene | Other Regulated Reactions | Isozyme | Ave. CR | Ave. SR | Remark |
|---|---|---|---|---|---|---|
| GPI | GPI | – | – | 0.931 | 0.981 | Gastric cancer [41]. |
| r0161 | AGXT | – | – | 0.933 | 0.982 | Colorectal cancer [45]. |
| r0249 | RPIA | RPI | – | 0.935 | 0.981 | Overestimated. |
| HMGLx | HMGCL | HMGLx | HMGCLL1 | 0.934 | 0.982 | Nasopharyngeal carcinoma [44]. |
| r0616 | PRODH2 | PROD2, r0615, PRO1x | – | 0.934 | 0.982 | Hepatocellular carcinoma [61]. |
| CATp | CAT | CATPm, r0010 | – | 0.932 | 0.982 | Related to ROS signaling [38,39,40]. |
| CATm | CAT | CATp, r0010 | – | 0.838 | 0.979 | Underestimated, ROS signaling [38,39,40]. |
| r0010 | CAT | CATm, CATp | – | 0.867 | 0.981 | Underestimated, ROS signaling [38,39,40]. |
Average similarity for flux change ratio; Average similarity ratio of the mutant flux pattern to the template; Brief description of gene function and references from PubMed and cancer databases.