. 2020 Jan 17;12(1):76. doi: 10.3390/pharmaceutics12010076

Table 4.

Thermal test done by using a hot plate for evaluation of the analgesic effect of geraniol micelles when it is used for prophylaxis from ischaemia/reperfusion injury in rat models.

		Groups
	Onset	Sham Operated	Positive Control	Vehicle (0.5 mL)	Geraniol Oil (0.02 mL)	Geraniol Micelles (0.25 mL)	Geraniol Micelles (0.5 mL)
Pre-Ischaemic/Reperfusion geraniol ttt	Base-line (Normal rats)	26.4 ± 1.29	26.4 ± 1.29	26.4 ± 1.29	26.4 ± 1.29	26.4 ± 1.29	26.4 ± 1.29
Pre-Ischaemic/Reperfusion geraniol ttt	72 h (once/24 h × 3 days)	28.4 ± 0.49	28.4 ± 0.49	21.8 ^ab ± 0.92	59.2 ^abc ± 0.72	65.8 ^abcd ± 1.19	58.3 ^abce ± 2.75
Post-Ischaemic/Reperfusion Geraniol ttt	24 h	31.4 ± 0.66	75 ^a ± 0	23.2 ^ab ± 1.68	33.4 ^bc ± 0.34	29.2 ^bcd ± 1.9	35.8 ^abce ± 0.59
Post-Ischaemic/Reperfusion Geraniol ttt	72 h (once/24 h × 3 days)	30.5 ± 0.64	0 ^a	0^a	39.4 ^abc ± 0.62	56.2 ^abcd ± 0.49	15.4 ^abcde ± 0.25

N = 8, results were expressed as means of seconds elapsed before licking the paw ± S.E. (a) means significantly different from sham-operated group; (b) significantly different from positive control (I/R) group; (c) significantly different from vehicle (0.5 mL) group; (d) significantly different from prophylactic geraniol oil (0.02 mL) group and (e) significantly different from prophylactic geraniol micelles (0.25 mL) group.