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. 2020 Jan 6;9(1):49. doi: 10.3390/antiox9010049

Figure 3.

Figure 3

Effects of the EA, LA, and Myrt on the apomorphine-induced rotational behavior in a rat model of Parkinson’s disease (PD). EA, LA, and Myrt (50 mg/kg, intraperitoneal (i.p.) injection) were administered daily for five days before stereotaxic surgery (unilateral injection of 2 μL/10 μg 6-hydroxydopamine (6-OHDA) into the right striatum). The test was made at the II and III weeks post lesion. The animals were observed for 30 min, beginning 1 min after the apomorphine injection (2 mg/kg, i.p). Data are expressed as the mean ±standard error of the mean (SEM) (n = 6–8 animals per group). Asterisks above bars indicate a significant difference in the number of rotations per minute for the 6-OHDA group versus the sham-operated (SO) group at ** p < 0.01; *** p < 0.001. Hashtags above the bar indicate a significant difference in the number of rotations per minute for each experimental group versus the 6-OHDA group at # p < 0.05; ## p < 0.01; ### p < 0.001. Statistical analysis used one-way analysis of variance (ANOVA) and Dunnett’s post hoc comparison test. For a detailed description of the groups, see section ‘Drug Treatment and Experimental Design’.