Table 5.

Pharmacokinetic parameters of TTX in rats after i.g. sustained-release TTX pellets administration at 150 μg/kg body wt. (n = 6, mean ± SD, median (range)).

Parameters	Unit	i.g. TTX of 150 μg/kg
C max	ng/mL	0.88 ± 0.22
T max	h	5 (3,5)
AUC0–t	ng·h/mL	10.77 ± 2.28
AUC0–∞	ng·h/mL	16.76 ± 2.93
t 1/2	h	14.52 ± 2.37
CL 1	mL/h/kg	9156.86 ± 1447.68
V d 2	mL/kg	192,752.13 ± 46,492.16
F	--	9.7%

¹ Total body clearance; ² steady state apparent volume of distribution.