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Intrinsic disorder propensities for amino acid sequence of Gαo from D. melanogaster. The plots were calculated in PONDR® FIT (solid line) and IsUnstruct (dashed line). Vertical dashed lines highlight the amino acid sequence region (65–180) forming domain II of Gαo. Blue line under the plot shows the region to be stabilized by disulfide bond introduction. Yellow circles show the exact positions of amino acid residues, between which the disulfide bond was designed.
