Table 6.

Optimal calculated variables, and the observed, predicted, and residual values for the responses.

Factor	Optimum	Response	Predicted	Observed	% Error
CTAB (mg/mL)	2.8	Particle size (nm)	133	143	6.8
CSO (mg/mL)	0.10	Zeta potential (mV)	30.6	28.2	8.51
PEG (mg/mL)	0.26	LE (%)	83.3	80.2	3.76
		LC (%)	8.34	7.94	4.79
Criterion for optimization = minimum particle size, ≥ ±20 mV of zeta potential, maximum LE and LCDesirability value = 0.96

Notes: % Error = [(observed value − predicted value)/observed value] × 100%.