Table 5.
Phenolic Mixture | Concentration Ratio (µg/mL) | Theoretical Effective Concentration (µg/mL) | Experimental Effective Concentration (µg/mL) | IF ± 95% Conf. | Effect |
---|---|---|---|---|---|
ECA:QPH | 1:4 | 2.09 | 1.81 ± 0.01 | 0.93 ± 0.01 | synergy |
1:2 | 1.80 | 1.81 ± 0.07 | 1.04 ± 0.04 | additivity | |
1:1 | 1.74 | 1.52 ± 0.01 | 0.98 ± 0.01 | additivity | |
2:1 | 1.48 | 1.38 ± 0.01 | 0.99 ± 0.01 | additivity | |
4:1 | 1.39 | 1.17 ± 0.01 | 0.91 ± 0.01 | synergy | |
ECA:CHA | 1:4 | 1.56 | 1.36 ± 0.03 | 0.89 ± 0.02 | synergy |
1:2 | 1.39 | 1.23 ± 0.01 | 0.85 ± 0.01 | synergy | |
1:1 | 1.41 | 1.24 ± 0.01 | 0.91 ± 0.01 | synergy | |
2:1 | 1.25 | 1.15 ± 0.08 | 0.89 ± 0.06 | synergy | |
4:1 | 1.26 | 1.04 ± 0.13 | 0.84 ± 0.10 | synergy | |
CHA:QPH | 1:4 | 2.19 | 2.00 ± 0.02 | 0.93 ± 0.01 | synergy |
1:2 | 1.97 | 1.89 ± 0.02 | 0.92 ± 0.01 | synergy | |
1:1 | 1.99 | 1.99 ± 0.09 | 1.03 ± 0.05 | additivity | |
2:1 | 1.78 | 1.87 ± 0.09 | 1.02 ± 0.05 | additivity | |
4:1 | 1.79 | 1.81 ± 0.19 | 1.03 ± 0.11 | additivity |
Results are mean values ± SD (n = 3). IF, interaction factor, calculated according to Equation (2). Codification of the phenolic compounds is given in Figure 1.