Table 2.

Influence of natural and synthetic CBD derivatives on receptor activation (X: agonist activation or Y: antagonist activation by related CBD derivative; * weak affinity; #: full name is in chapter 4.1) [2,24,72,76,114,115,116,120,122,123,124,125,126,127,130].

CBD Derivatives	Membrane Receptors
Natural	CB1	CB2	Gpr55	Gpr18	TRPV1	TRPA1	TRPM8	5-HT1A	PPARγ
cannabigerol (CBG)					X			X
cannabigivarin (CBGV)					X
cannabidiolic acid (CBDA)	X *	X *			X	X	Y
cannabidivarin (CBDV)	X *	X *	Y
cannabimovone	X *	X *			X
7-OH-CBD	X *	X *
7-COOH-CBD	X *	X *
Synthetic	CB1	CB2	Gpr55	Gpr18	TRPV1	TRPA1	TRPM8	5-HT1A	PPARγ
(−)-dimethylheptyl-CBD (DMH-CBD)	X
(−)-7-hydroxy-5′-dimethylheptyl-CBD	X *	X *
(−)-1-COOH-5′-dimethylheptyl-CBD	X *	X *
(+)-5′-dimethylheptyl-CBD	X	X *
(+)-7-hydroxy-5′-dimethylheptyl-CBD	X	X *
(+)-dihydrocannabidiol (H2-CBD)	X
(+)-tetrahydrocannabidiol (H4-CBD)	X
(-)-8,9-dihydro-7-hydroxy-CBD (HU-446)	X *	X *
(+)-8,9-dihydro-7-hydroxy-CBD (HU-465)	X	X
pinene dimethoxy-dimethylheptyl-CBD derivative (HU-433)		X *
pinene dimethoxy-dimethylheptyl-CBD derivative (HU-308)		X
HU-910 #		X
4′-fluorocannabidiol (HUF-101/4′-F-CBD)	X	X
quinol derivative VCE-003									X
quinol derivative HU-331									X
abnormal-CBD			X	X