Table 7.
Pharmacokinetics of catalpol in different studies.
| Sample | Rat Plasma | Rat Plasma | Rat Plasma | Rat Plasma | Rat CSF |
|---|---|---|---|---|---|
| Dose | 50 mg/kg, p.o. | 6 mg/kg, i.v. | 10 mg/kg, i.v. | 8 mg/kg, p.o. | 6 mg/kg, i.v. |
| Tmax (h) | 1.333 ± 0.408 | - | - | 2.8 ± 0.837 | 0.08 ± 0.02 |
| Cmax (ng/mL) | 23,318 ± 10,468 | 23 617.4 ± 914.7 | - | 1680 ± 120 | 675.9 ± 198.4 |
| T1/2 (h) | 1.212 ± 0.388 | 0.71 ± 0.23 | 0.984 ± 0.229 | 3.275 ± 1.192 | 1.52 ± 0.74 |
| AUC (0–t) | - | 11 432.3 ± 1582.5 ng·h/mL | 5951.125 ± 1247.247 µg·h/L | 584.80 ± 107.29 µg·min/mL | 594.5 ± 81.3 ng·h/mL |
| AUC (0–∞) | 69,520 ± 22,927 ng·h/mL | 11 532.9 ± 1643.0 ng·h/mL | 5954.076 ± 1248.205 µg·h/L | 666.30 ± 194.60 µg·min/mL | 671.5 ± 109.1 ng·h/mL |
| MRT (0–∞) (h) | 3.273 ± 0.365 | 0.70 ± 0.20 | 0.0454 ± 0.140 | - | 2.12 ± 1.0 |
| V (L/kg) | 1.428 ± 0.681 | - | 0.348 ± 0.075 | - | - |
| CL (L/h/kg) | 0.824 ± 0.317 | - | 0.348 ± 0.075 | 0.9 ± 0.24 | - |
| Method | LC/MS/MS | HPLC–APCI–MS/MS | LC–ESI-MS/MS | UPLC–MS | HPLC–APCI–MS/MS |
| Reference | [107] | [108] | [105] | [109] | [108] |