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. 2020 Jan 13;10(1):143. doi: 10.3390/nano10010143

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Radiolabeling of C₆₀-NOTA. (A) Radiolabeling reaction scheme; (B) Radio-HPLC chromatograms of [⁶⁴Cu]CuCl₂ (red), [⁶⁴Cu]Cu(NOTA) (black), and C₆₀-[⁶⁴Cu]Cu(NOTA) (gray), C₆₀-[⁶⁴Cu]Cu(NOTA) challenged against PBS at 25 °C for 24 h (orange), C₆₀-[⁶⁴Cu]Cu(NOTA) challenged against human serum at 37 °C for 20 h (blue), mouse urine sample at 20 min p.i. (green), and mouse blood sample at 20 min p.i. (yellow).