Figure 6.

PET images and biodistribution of [⁶⁴Cu]Cu(NOTA). (A) Whole-body dynamic and static PET images acquired at various time points post-injection (p.i.). Organs labeled are brain (B), heart (H), kidney (K), and bladder (BL). White arrows for 3 and 24 h p.i. images highlight a breathing pad that was placed under the mice during imaging. The radioactivity was negligible at 48 h p.i., so it could not be imaged and quantified accurately, suggesting that [⁶⁴Cu]Cu(NOTA) was no longer present in vivo at 48 h p.i.; (B) The time activity curve (TAC) of a 20 min dynamic scan showing initial biodistribution and rapid drop-off in uptake in most organs; (C) Quantification of radioactivity in various organs with a vertically expanded view of the graph to highlight lower accumulation. Data represent mean ± SEM, n = 6.