Table 3.
Effects of maternal exposure to T-2 toxin on the capacity of antioxidant system and DNA damage in the testes of offspring.
| Dose | CAT (U/mgprot) | MDA (nmol/mgprot) | SOD (U/mgprot) | GSH-Px (U/mgprot) | 8-OHdG (ng/gprot) |
|---|---|---|---|---|---|
| (mg/kg) | |||||
| PND 21 | |||||
| 0 | 29.00 ± 3.72 | 0.45 ± 0.03 | 395.69 ± 55.09 | 14.64 ± 3.47 | 25.24 ± 4.28 |
| 0.005 | 29.04 ± 1.82 | 0.53 ± 0.01 ** | 526.81 ± 27.48 ** | 14.83 ± 4.67 | 49.94 ± 3.16 ** |
| 0.05 | 14.58 ± 2.82 ** | 1.22 ± 0.02 ** | 282.77 ± 14.58 * | 4.13 ± 0.52 * | 26.03 ± 2.88 |
| PND 28 | |||||
| 0 | 14.07 ± 1.11 | 2.06 ± 0.40 | 329.75 ± 22.31 | 9.18 ± 2.20 | 26.04 ± 1.76 |
| 0.005 | 12.60 ± 3.65 | 2.21 ± 0.24 | 292.21 ± 15.83 | 6.66 ± 1.28 | 20.12 ± 0.81 ** |
| 0.05 | 9.62 ± 1.11 | 1.86 ± 0.06 | 215.38 ± 16.05 ** | 5.76 ± 0.31 | 15.39 ± 0.48 ** |
| PND 56 | |||||
| 0 | 23.12 ± 3.65 | 1.42 ± 0.48 | 230.43 ± 12.03 | 6.74 ± 0.48 | 15.14 ± 0.99 |
| 0.005 | 30.29 ± 4.11 | 1.88 ± 0.30 | 263.19 ± 14.59 * | 7.80 ± 0.32 | 17.87 ± 1.39 |
| 0.05 | 22.55 ± 1.22 | 1.85 ± 0.05 | 220.58 ± 3.24 | 6.31 ± 0.60 | 12.34 ± 1.84 |
Each value represents the mean ± SEM of the group (n = 4). * p < 0.05, ** p < 0.01: compared with the control (0 mg/kg T-2 toxin).