Table 6.
Fold-change of discriminants metabolites from binning data in mouse liver extracts induced by the COCO and FISH diets compared to the REF diet.
| Metabolites a | FC b COCO | FC b FISH |
|---|---|---|
| FA (CH2)n | 0.71 * | 0.82 |
| EPA+ARA | 0.67 * | 0.80 |
| FA CH3 | 0.73 * | 0.80 |
| Linoleic acid | 0.28 * | 0,92 |
| MUFA | 1.99 * | 0.84 |
| PC+LPC+SM | 0.61 * | 0.94 |
| PL (Except LPC) | 0.65 * | 1.15 |
| TG | 1.63 * | 0.98 |
| 3-Hydroxybutyrate | 1.21 * | 1.10 |
| Alanine | 1.30 * | 0.97 |
| Choline | 1.02 | 1.68 * |
| Glucose | 0.88 * | 0.88 * |
| Glutamine | 1 | 1.18 * |
| Glutathione | 1.07 | 1.30 * |
| GPC | 1.39 * | 1.61 * |
| Inosine | 1.24 * | 1 |
| Lactate | 1.27 * | 1.14 * |
| Leucine | 1.23 * | 1.11 * |
| Phenylalanine | 1.32 * | 1.15 |
| Succinate | 1.50 * | 1.38 * |
| Threonine | 1.28 * | 1.03 |
| Tyrosine | 1.47 * | 1.28 * |
| Valine | ↑1.21 * | 1.07 |
a Metabolites that were significantly different between groups; relative integrations of buckets were compared between groups with the Kruskal-Wallis test and a multiple test correction (p < 0.05). bFC, Fold Change = test diet/control diet. * indicates a significative difference between diets. Abbreviations: COCO, a diet with 5% saturated FA-rich oil; REF, a diet with 5% reference oil; FISH, a diet with 5% n-3 long-chain PUFA-rich oil; FA, fatty acids; EPA, eicosapentaenoic acid; ARA, arachidonic acid; MUFA, monounsaturated FAs; PC, phosphatidylcholine; LPC, lysophosphatidylcholine; SM, sphingomyelin; PL, phospholipids; TG, triglycerides; GPC, glycerophosphocholine.