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Summary of the two main formulations for the NCs. Oleic acid coated-SPIONs and PLGA-BPLP and PLGA-PEG were mixed in the organic phase during the double miniemulsion process.
| NCs Type | Shell Polymers (wt%) | SPIONs Loading (wt%) | Ms (eum/g) | Size (DLS) | BSA Loading (wt%) | BSA EE% | |||
|---|---|---|---|---|---|---|---|---|---|
| PLGA | PLGA-BPLP * | PLGA-PEG | d. nm | PdI | |||||
| NC1.non-PEGylated | 10 | 90 | / | 5.7 | 4.0 | 272 | 0.11 | 0.96 | 38.5 |
| NC2.PEGylated | 3 | 90 | 7 | 6.0 | 4.2 | 265 | 0.05 | 1.01 | 41.3 |
* PLGA-BPLP from initial molar ratios (LA:GA):BPLP = (75:25):1.
