Table 1.
Characteristics of all pregnant women.
Characteristics | Patient #1 | Patient #2 | Patient #3 | Patient #4 | Patient #5 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
days after symptoms onset | 5 | 16 | 31 | 59 | 74 | 165 | 198 | 107 | 154 | 34 | 95 | 11 | 56 | 60 | 3 months post-partum |
ZIKV RNA in blood | Pos | Pos | Pos | Pos | Pos | Pos | Neg | Pos | Pos | Pos | Pos | Neg | |||
ZIKV RNA in urine | Pos | Pos | Neg | Pos | Neg | Neg | Pos | Neg | |||||||
ZIKV RNA in saliva | Pos | Neg | Neg | Neg | Pos | Neg | Neg | ||||||||
ZIKV RNA in AF | Neg | Neg | Pos | ||||||||||||
ZIKV IgM EIA | Neg | Neg | Neg | Neg | Neg | Neg | Pos | Neg | Neg | ||||||
ZIKV IgG EIA | Pos | Pos | Pos | Pos | Pos | Pos | Neg | Pos | Pos | ||||||
ZIKV NT Abs | 1:640 | 1:1280 | 1:2560 | 1:160 | 1:160 | 1:2560 | 1:2560 | ||||||||
DENV IgM EIA | Neg | Neg | Neg | Neg | Neg | Neg | Neg | ||||||||
DENV IgG EIA | Pos | Pos | Pos | Pos | Pos | Pos | Pos | ||||||||
DENV NT Abs | |||||||||||||||
DENV1 | 1:2560 | 1:40,000 | 1:640,000 | 1:5000 | 1:320 | <5 | <5 | ||||||||
DENV2 | 1:160,000 | 1:640,000 | 1:640,000 | 1:320 | 1:320 | <5 | <5 | ||||||||
DENV 3 | 1:640,000 | 1:640,000 | 1:640,000 | 1:640 | 1:320 | <5 | <5 | ||||||||
DENV 4 | 1:640 | 1:2560 | 1:640,000 | 1:80 | 1:80 | <5 | <5 | ||||||||
BOB assay * | 0.179 | 0.197 | 0.156 | 0.151 | 0.165 | ||||||||||
ZIKV ELISPOT ** | 61 | 81 | |||||||||||||
DENV ELISPOT ** | |||||||||||||||
DENV1 | 153 | 5 | 3 | ||||||||||||
DENV2 | 163 | 5 | 28 | ||||||||||||
DENV 3 | 198 | 3 | 0 | ||||||||||||
DENV 4 | 118 | 10 | 30 | ||||||||||||
outcome | no transmission | no transmission | no transmission | transmission | transmission |
* Blockade-of-binding (BOB) assay: cut off 0.36 (confirmed Zika virus (ZIKV) Ab < 0.36), all results are expressed in ratio; ** responses are given as net spots/million PBMC, cut-off of response 30 net spots/million PBMC; EIA: enzyme immunoassay; AF: amniotic fluid; NT Abs: neutralizing antibodies; results of NT Abs < 5 are considered negative. DENV, Dengue virus.