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. 2019 Dec 19;10(1):11. doi: 10.3390/biom10010011

Figure 3.

Figure 3

Effects of melatonin on renal oxidative damage in AAN. (A) Representative images of immunohistochemical staining using anti-4-hydroxynonenal (4-HNE) antibody. Scale bar: 25 μm. (B) Percentage of 4-HNE positive area per field. (C) Renal malondialdehyde (MDA) level. Real-time reverse transcription-polymerase chain reaction analysis of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) (D), cytochrome P450 2E1 (CYP2E1) (E), superoxide dismutase 2 (SOD2) (F), catalase (G), and glutathione synthetase (GSS) (H) in kidneys. n = 8 per group. All data are presented as the mean ± SEM. *** p < 0.001 vs. Veh. # p < 0.05, ## p < 0.01, and ### p < 0.001 vs. AA.