Treatment with phenyl isothiocyanate (P-ITC) decreases the mechanical allodynia and the grip strength deficits induced by the intra-articular injection of MIA. The development of (A) the mechanical allodynia in the ipsilateral paw and (B) the grip strength deficits in the hind paws of the MIA- or SS-injected mice treated with P-ITC or vehicle for 10 consecutive days are presented. The effects of P-ITC were assessed at days 20, 22, 25, and 29 after MIA or SS injection. For each test and time evaluated, * denotes significant differences vs. their respective SS-injected mice, and $ denotes significant differences vs. MIA-injected mice treated with P-ITC (p < 0.05; one-way ANOVA followed by the Student–Newman–Keuls test). The results are shown as the mean values ± SEM; n = 6 animals per experimental group.