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. 2019 Dec 29;9(1):31. doi: 10.3390/antiox9010031

Figure 6.

Figure 6

The administration of XE-991 reverses the antidepressant effects of A-ITC and P-ITC in mice with chronic osteoarthritis pain. The immobility time (s) evaluated with the (A) TST and (B) FST in mice treated for 4 or 10 consecutive days with A-ITC or P-ITC alone and combined with the selective Kv7 potassium channel blocker XE-991 is shown. The effects of XE-991 administered alone are also represented. For each test evaluated, * denotes significant differences vs. saline–saline-injected mice treated with vehicle and + denotes significant differences vs. MIA–saline-injected mice treated with a drug (p < 0.05; one-way ANOVA followed by the Student–Newman–Keuls test). The results are shown as the mean values ± SEM; n = 6–8 animals per experimental group.