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Experiment design. After one week of adaption, rats were divided randomly into five groups: (1) vehicle control (VC, n = 6); (2) STZ (60 mg/kg, single intraperitoneal (i.p.) injection); (3) STZ (60 mg/kg, single i.p. injection) + DP (25 mg/kg/day, oral gavage); (4) DP extract (25 mg/kg/day, oral gavage); and (5) STZ (60 mg/kg, single i.p. injection) + Mef (50 mg/kg/day, oral gavage). DP and Mef were administered daily for 4 weeks by oral gavage. STZ, streptozotocin; Mef, metformin.
