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. 2019 Dec 19;10(1):9. doi: 10.3390/biom10010009

Scheme 1.

Scheme 1

Synthesis of PABA-based imines 1a1t (R1 = H, 5-F, 4-Cl, 5-Cl, 6-Cl, 5-Br, 5-I, 5-NO2, 5-CH3, 5-OCH3, 5-OH, 5-t-Bu; R2 = H, Cl, Br, I; R3 = 2-OCH3, 4-OH; TsOH = toluene-4-sulfonic acid; DEE = diethyl ether).