Table 4.
Cytotoxicity of the compounds 1 for HepG2 cells.
| Code | R1 | R2 | IC50 [µM] | Range of Concentrations Tested |
|---|---|---|---|---|
| 1a | H | H | >1500 * | 1–1500 |
| 1b | 5-F | H | 497.6 | 1–500 |
| 1c | 5-Cl | H | 142.9 | 1–500 |
| 1d | 5-Br | H | 178.7 | 1–500 |
| 1e | 5-I | H | 113.4 | 1–500 |
| 1f | 5-NO2 | H | 243.8 | 1–500 |
| 1g | 5-CH3 | H | 956.4 | 1–1500 |
| 1h | 5-CH3O | H | 530.4 | 1–1500 |
| 1i | 5-OH | H | ND | 1–1500 |
| 1j | 5-tert-Bu | H | 80.8 | 1–500 |
| 1k | 6-Cl | H | 279.6 | 1–500 |
| 1l | 4-Cl | H | 263.9 | 1–500 |
| 1m | H | Cl | 247.4 | 1–500 |
| 1n | 5-Cl | Cl | 98.7 | 1–500 |
| 1o | 5-Cl | Br | 85.7 | 1–500 |
| 1p | 5-Cl | I | 53.4 | 1–500 |
| 1q | 5-I | I | 57.8 | 1–500 |
| 1r | - | - | 15.0 | 1–500 |
| 1s | - | - | 1090.0 | 1–1500 |
| 1t | - | - | >1500 * | 1–1500 |
| 1u | - | - | >500 * | 1–500 |
| Tamoxifen | - | - | 19.6 | 1–500 |
| Cisplatin | - | - | 21.3 | 1–500 |
| PABA 1 | - | - | >1500 * | 1–1500 |
* measurement at higher concentration was unable due to the precipitation of the compound in the medium. PABA = 4-aminobenzoic acid; ND = not determined.