Table 2.
Average size, polydispersity index, zeta (Z)-potential, entrapment efficiency, and drug loading of nanoparticles (NPs) at 25 °C. Data are mean values ± SD (n = 3). PI—polydispersity index; MTX—methotrexate; EE—encapsulation efficiency; DL—drug loading.
| Formulation | Size (nm) | PI | Z-Potential (mV) | EE% MTX | DL % |
|---|---|---|---|---|---|
| FTC1 | 364.2 ± 3.1 | 0.167 | +28.3 ± 1.04 | - | |
| FTC2 | 202.4 ± 5.8 | 0.254 | +35.9 ± 0.36 | - | |
| FTC3 | 234.7 ± 7.9 | 0.234 | +24.9 ± 1.4 | - | |
| CHT | 378.4 ± 7.4 | 0.318 | +30.7 ± 3.35 | - | |
| FTC1-MTX | 363.9 ± 3.3 | 0.154 | +26.3 ± 1.18 | 55.92 ± 2.88 | 18.64 ± 0.28 |
| FTC2-MTX | 258.3 ± 4.9 | 0.153 | +28.9 ± 0.47 | 37.44 ± 5.22 | 12.48 ± 0.52 |
| FTC3-MTX | 302.0 ± 9.3 | 0.250 | +26.8 ± 1.89 | 18.28 ± 9.87 | 6.09 ± 0.99 |
| CHT-MTX | 364.1 ± 2.5 | 0.273 | +26.7 ± 0.99 | 55.15 ± 4.52 | 18.38 ± 0.45 |