Table 2.
Particle size, zeta potential, polymer glass transition temperature (Tg), encapsulation efficiency (EE), and DOX loading content of DOX-PLGA NP and DOX-PLGA-di-GAL NP.
| System | Particle Size (nm) a | Zeta Potential (mV) a | Tg (°C) b | EE (% w/w) c | DOX Content (% w/w) d |
|---|---|---|---|---|---|
| PLGA | 43.32 | ||||
| PLGA-di-GAL | -- | -- | 44.47 | -- | -- |
| PLGA NP | 238 ± 48 | −18.4 | 45.55 | -- | -- |
| PLGA-di-GAL NP | 311 ± 58 | −30.3 | 44.14 | -- | -- |
| DOX-PLGA NP | 239 ± 43 | −71.7 | 44.9 | 65 ± 10 | 2.9 ± 0.4 |
| DOX-PLGA-di-GAL NP | 258 ± 47 | −62.3 | 45.69 | 83 ± 9 | 3.7 ± 0.4 |
a measured by DLS; b measured by DSC; c encapsulation efficiency calculated as the ratio between DOX content in the particles and the DOX added at the particles preparation; d calculated as the ratio between DOX content and particles quantity.