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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Org Lett. 2019 Sep 9;21(18):7394–7399. doi: 10.1021/acs.orglett.9b02713

Table 1.

Cell viability data (alamar blue assay, 72 h incubation) of select intermediates toward Sinularia natural products.a

graphic file with name nihms-1556763-t0002.jpg graphic file with name nihms-1556763-t0003.jpg graphic file with name nihms-1556763-t0004.jpg graphic file with name nihms-1556763-t0005.jpg graphic file with name nihms-1556763-t0006.jpg
MDA MB 231 (EC50, μM) >100 >100 >100 >100 >100
HCT 116 (EC50, μM) >100 28.90 ± 6.36 >100 >100 >100
A549 (EC50, μM) >100 >100 >100 >100 >100
HUVEC (EC50, μM) >100 >100 >100 >100 >100
graphic file with name nihms-1556763-t0007.jpg graphic file with name nihms-1556763-t0008.jpg graphic file with name nihms-1556763-t0009.jpg graphic file with name nihms-1556763-t0010.jpg graphic file with name nihms-1556763-t0011.jpg
MDA MB 231 (EC50, μM) 77.70 ± 21.63 45.40 ± 7.97 >100 45.20 ± 10.19 10.52 ± 2.21
HCT 116 (EC50, μM) >100 >100 >100 2.97 ± 0.50 0.39 ± 0.03
A549 (EC50, μM) >100 >100 >100 5.69 ± 0.75 3.26 ± 0.35
HUVEC (EC50, μM) 62.91 ± 6.32 48.66 ± 4.07 >100 6.88 ± 0.73 3.89 ± 0.33
a

Rameswaralide was previously assayed only against the A549 cell line (IC50 of 67 ± 3.7 μM).8

b

See SI for synthetic details.

c

Analogs 34-36, were kindly provided by Prof. Brian Stoltz (Caltech).52