Table 1.
miRNAs mediated regulation of BCBM
| miRNA | Targets | Regulation | References |
|---|---|---|---|
| EMT | |||
| miR-8084 | ING2, p53-BAX | upregulated | [16] |
| miR-484 | PAX-5 | upregulated | [19] |
| miR-708-3p | ZEB1, CDH2 and vimentin | downregulated | [17] |
| miR-210 | E-cadherin (ORF), PAX-5 | upregulated | [19] |
| miR-142-3p | Bach-1, CXCR4, MMP9, and VEGFR | downregulated | [18] |
| miR-199a/214 | Slug | downregulated | [51] |
| miR-3178 | Notch1 | downregulated | [52] |
| miR-212-5p | Prrx2 | downregulated | [53] |
|
miR-29,miR-30 miR-200 family |
ADAM12-L | downregulated | [54] |
| Intravasation | |||
| miR-126 | VEGF/PI3K/AKT axis, MAPK | downregulated | [30] |
| miR-520/373 | ANGPTL4, PTHrP, PAI-1 | downregulated | [25] |
| miR-204 | ANGPT1 and TGFβR2 | downregulated | [24] |
| miR-200 family | IL-8 and CXCL1 | downregulated | [27] |
| miR-105 | ZO-1 | downregulated | [29] |
| Intravascular Microenvironment | |||
| miR-141 | Protection in circulation | upregulated | [31] |
| miR-183 | DAP12/NK cells | downregulated | [32] |
| Extravasation in Brain Microenvironment | |||
| miR-7, let-7c, miR-21 | FasL, SERPIN1 | upregulated | [55] |
| miR-200c | FAP-1 | downregulated | [56] |
| miR-206 | Cx43 | downregulated | [57] |
| miR-19a, miR-32,miR-124a, miR-130b, miR-148a, and miR-583 | PCTH7 | downregulated | [58] |
| miR-125a/b-5p | ET-1 | downregulated | [59] |
| miR-1266, miR-185 and miR-30c | BCL2L1 | downregulated | [60] |
| miR-151-3p | TWIST1 | downregulated | [61] |
| miR-17 | ICAM-1and E-Selectin | downregulated | [62] |
| miR-126 and miR-1185 | VCAM1 | downregulated | [63] |
| miR-483-5p | ALCAM | downregulated | [64] |
| miR-21-3p | L1CAM | upregulated | [34] |
| miR-212 | HBEGF | downregulated | [65] |
| miR-655 | COX2 | downregulated | [66] |
| miR-200b, 200c | ST6GALNAC5 | downregulated | [67, 68] |
| BBB Regulation | |||
| miR-181c | PDPK1 | upregulated | [69] |
| miR-143 | PUMA | upregulated | [35] |
| miR-125a-5p | ICAM-1 | downregulated | [38] |
| miR-1258 | HPSE | downregulated | [40] |
| miR-210 | Occludin, β-catenin | upregulated | [37] |
| Cross Talk and Niche Formation | |||
| miR-26a |
PTEN ATM |
upregulated | [70, 71] |
| miR-19a | PTEN | upregulated | [42] |
| miR-345 | KISS1 | upregulated | [72] |
| miR-124, miR-155, miR-689 | Associated with M1 phenotype of microglia | upregulated | [73] |
| miR-711 and miR-145 | Associated with M2 phenotype of microglia | upregulated | [73] |
| miR-503 |
L1CAM trigger M1–M2 polarization of microglia |
upregulated | [41] |
| Metabolic Reprogramming | |||
| miR-122 | PKM2 , GLUT-1 | upregulated | [74] |
| miR-155 | PIK3R1-PDK/AKT-FOXO3a-cMYC axis | downregulated | [75] |
| miR-7 | RelA | upregulated | [76] |
| Colonization | |||
| miR-200 family (miR-200a,200b, 200c, miR-141, and miR-429) | ZEB1 and ZEB2 | upregulated | [43, 44] |
| miR-147 | ZEB1 | upregulated | |
| miR-126 | IGFBP2, PITPNC1 and MERTK | downregulated | [77] |